{"id":4137,"date":"2021-12-16T17:51:35","date_gmt":"2021-12-16T17:51:35","guid":{"rendered":"https:\/\/biotechsa.com\/2\/?p=4137"},"modified":"2026-03-10T13:01:22","modified_gmt":"2026-03-10T19:01:22","slug":"a-novel-protein-therapy-for-efficient-skin-wound-healing","status":"publish","type":"post","link":"https:\/\/biotechsa.com\/2\/noticias\/a-novel-protein-therapy-for-efficient-skin-wound-healing\/","title":{"rendered":"A novel protein therapy for efficient skin wound healing"},"content":{"rendered":"\n
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A group of researchers at A*STAR\u2019s (Agency for Science, Technology and Research) Institute of Molecular and Cell Biology (IMCB) have identified a new protein to aid in wound healing and repair, according to an article published on Medical Xpress. Complications in the healing of chronic wounds are a leading cause of amputation and decreased emotional wellbeing for patients; specifically, those suffering from diabetes or burns. Delayed wound healing arises when tissue is injured and components of the extracellular matrix (ECM) are lost. The ECM provides key proteins that help rebuild tissue so its loss during injury can leave the body without its natural scaffold for restoration.<\/p>\n

An initial study was conducted on both human and pre-clinical models whereby researchers found that when physical injury occurs to skin tissue, an upregulation of the protein \u2018Agrin\u2019 is produced by the ECM to preserve the mechanical architecture of injured skin layers by repairing the tissue. This led scientists to deduce that supplementation of the protein Agrin could promote accelerated healing by providing a bio-scaffold.<\/p>\n

In collaboration with the Mechanobiology Institute at the National University of Singapore, researchers then discovered a recombinant fragment of the Agrin protein that could be easily produced, called sAgrin. They found that sAgrin offered accelerated healing as a topical hydrogel when compared to commercially available collagen gels. In addition to providing faster healing, Agrin therapy also better preserved the wound microenvironment that promotes better repair mechanisms compared to control groups.<\/p>\n

\u201cThe findings offer the potential for developing Agrin-based wound healing biomaterials that could help patients with chronic wounds,” said Dr. Sayan Chakraborty, lead researcher of the study. While recent studies from various labs accept the importance of Agrin in the repair and regeneration of tissues and organs, extended testing of sAgrin is needed to improve its efficacy and to develop bio-printed scaffolds that could help repair damaged tissue.<\/p>\n

Click here to read the full article.<\/a><\/p>\n

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TRADUCCI\u00d3N DE GOOGLE:<\/span><\/strong><\/p>\n

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Una nueva terapia con prote\u00ednas para la cicatrizaci\u00f3n eficaz de heridas en la piel.<\/h3>\n

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Un grupo de investigadores del Instituto de Biolog\u00eda Molecular y Celular (IMCB) de A * STAR (Agencia de Ciencia, Tecnolog\u00eda e Investigaci\u00f3n) ha identificado una nueva prote\u00edna para ayudar en la curaci\u00f3n y reparaci\u00f3n de heridas, seg\u00fan un art\u00edculo publicado en Medical Xpress. Las complicaciones en la curaci\u00f3n de heridas cr\u00f3nicas son una de las principales causas de amputaci\u00f3n y disminuci\u00f3n del bienestar emocional de los pacientes; en concreto, los que padecen diabetes o quemaduras. La cicatrizaci\u00f3n tard\u00eda de las heridas surge cuando el tejido se lesiona y se pierden componentes de la matriz extracelular (MEC). El ECM proporciona prote\u00ednas clave que ayudan a reconstruir el tejido para que su p\u00e9rdida durante una lesi\u00f3n pueda dejar al cuerpo sin su andamio natural para la restauraci\u00f3n.<\/p>\n

Se realiz\u00f3 un estudio inicial en modelos humanos y precl\u00ednicos mediante el cual los investigadores encontraron que cuando se produce una lesi\u00f3n f\u00edsica en el tejido de la piel, el ECM produce una regulaci\u00f3n positiva de la prote\u00edna ‘Agrin’ para preservar la arquitectura mec\u00e1nica de las capas cut\u00e1neas lesionadas mediante la reparaci\u00f3n de la pa\u00f1uelo de papel. Esto llev\u00f3 a los cient\u00edficos a deducir que la suplementaci\u00f3n con la prote\u00edna Agrin podr\u00eda promover una curaci\u00f3n acelerada al proporcionar un bioandamio.<\/p>\n

En colaboraci\u00f3n con el Instituto de Mecanobiolog\u00eda de la Universidad Nacional de Singapur, los investigadores luego descubrieron un fragmento recombinante de la prote\u00edna Agrin que podr\u00eda producirse f\u00e1cilmente, llamado sAgrin. Descubrieron que sAgrin ofrec\u00eda una curaci\u00f3n acelerada como hidrogel t\u00f3pico en comparaci\u00f3n con los geles de col\u00e1geno disponibles comercialmente. Adem\u00e1s de proporcionar una curaci\u00f3n m\u00e1s r\u00e1pida, la terapia con Agrin tambi\u00e9n preserv\u00f3 mejor el microambiente de la herida que promueve mejores mecanismos de reparaci\u00f3n en comparaci\u00f3n con los grupos de control.<\/p>\n

“Los hallazgos ofrecen el potencial para desarrollar biomateriales de curaci\u00f3n de heridas basados \u200b\u200ben Agrin que podr\u00edan ayudar a los pacientes con heridas cr\u00f3nicas”, dijo el Dr. Sayan Chakraborty, investigador principal del estudio. Si bien los estudios recientes de varios laboratorios aceptan la importancia de Agrin en la reparaci\u00f3n y regeneraci\u00f3n de tejidos y \u00f3rganos, se necesitan pruebas m\u00e1s extensas de sAgrin para mejorar su eficacia y desarrollar andamios bioimpresos que podr\u00edan ayudar a reparar el tejido da\u00f1ado.<\/p>\n

Click here to read the full article.<\/a><\/p>\n

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