{"id":1888,"date":"2020-09-17T16:29:08","date_gmt":"2020-09-17T16:29:08","guid":{"rendered":"https:\/\/biotechsa.com\/2\/?p=1888"},"modified":"2026-03-10T12:58:06","modified_gmt":"2026-03-10T18:58:06","slug":"new-treatment-for-drug-resistant-bacterial-infections","status":"publish","type":"post","link":"https:\/\/biotechsa.com\/2\/noticias\/new-treatment-for-drug-resistant-bacterial-infections\/","title":{"rendered":"New treatment for drug-resistant bacterial infections"},"content":{"rendered":"
<\/span><\/div>

ScienceDaily has recently reported on a study by Dartmouth Engineering faculty to more effectively target Methicillin-Resistant Staphylococcus Aureus (MRSA). Finding an effective treatment for MRSA is considered a priority by the Centers for Disease Control and Prevention (CDC) as it is the deadliest drug-resistant pathogen in the United States. The research team has since developed a promising lysin-based antibacterial agent that will not cause hypersensitivity reactions from the immune system and allows for repeated dosing in persistent cases.<\/p>\n

Lysins are enzymes naturally produced by microbes that have shown promise in treating both drug-resistant and drug-vulnerable S. aureus infections by potentially suppressing new resistance phenotypes developed by bacteria. While lysins are one of the most promising next-generation antibiotics, they can cause a strong antibody reaction from the immune system leading to life-threatening reactions. However, lead author, Karl Grisworld explains that their newly engineered treatment, named F12 is largely safe for the immune system thanks to a \u201cT cell epitope deletion.\u201d<\/p>\n

This antimicrobial agent is the first of its kind and has resulted positively as treatment in rabbits and mice with partially-humanized immune systems. \u201cThis is the first report of a translation-ready deimmunized lysin, and F12 has serious, bonafide clinical potential,” said Griswold. He believes that the agent could be ready for human clinical trials as soon as 2023.<\/p>\n<\/div><\/div>

Click here to view the full article.<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div>

\n\n