In an article shared by Medical Xpress, new research suggests that three commonly prescribed classes of drugs (proton pump inhibitors, beta-blockers and antimetabolites) could lead to antibiotic resistant infections caused by bacteria from the Enterobacteriaceae family. As a result, these infections can be linked to longer hospital stays and an increased risk of death.
This study, which was presented at the European Congress of Clinical Microbiology & Infectious Diseases, examined data from 1,807 adults admitted between 2017 and 2019 with positive cultures growing Enterobacteriaceae. The study identified the use of 19 non-antimicrobial drug (NAMD) classes prior to hospital admission. Ultimately, antimicrobial drug-resistant organisms were found in over half of patient samples and multidrug-resistant organisms were identified in around a quarter of episodes. This study also found that commonly used NAMDs have a significant impact on the bacterial composition of the gut microbiome and pose a possible risk for antibiotic resistance.
Lead author on the study, Dr. Meital Elbaz of Tel Aviv Medical Center in Israel states “Our findings highlight the importance of non-antimicrobial drug exposure as a risk factor for antibiotic resistance. We urgently need larger studies with more drug classes to confirm the discovery and to clarify the biological link between common prescription drugs and antibiotic resistance.”
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